Tirzepatide produces effects in the body similar to those of incretin hormones, a group of hormones naturally released when food is consumed. These hormones signal the brain, gastrointestinal system, and endocrine organs to indicate food intake, triggering a cascade of hormonal and neurotransmitter responses that lead to feelings of satiety or fullness. They also play a crucial role in regulating blood sugar levels, improving glucose control in individuals with impaired glucose metabolism or diabetes.

 

To break it down further, tirzepatide mimics the effects of two key incretin hormones: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). These hormones work together across several organ systems to support metabolism and blood sugar regulation:

 

• In the brain, tirzepatide activates GLP-1 receptors in the hypothalamus, the region of the brain responsible for regulating appetite and thirst. This signals the brain to reduce hunger, helping you feel satisfied and stop eating.

  

• In the muscles, tirzepatide promotes gluconeogenesis by helping convert protein and fats into glucose, providing fuel for muscle activity. This process helps maintain energy balance and supports muscle function.

  

• In the stomach, tirzepatide slows the rate at which food is digested and moves through the stomach, enhancing feelings of fullness after eating and reducing the desire for larger portions.

  

• In the liver, tirzepatide inhibits hepatic glucose production (gluconeogenesis), reducing the amount of glucose released into the bloodstream. This helps lower blood sugar levels, particularly in people with impaired glucose metabolism.

  

• In the pancreas, tirzepatide acts on both GLP-1 and GIP receptors to stimulate insulin production and suppress glucagon secretion. This leads to improved blood sugar control by enhancing insulin response and preventing excess glucose production, which is especially beneficial for individuals with prediabetes, type 2 diabetes, or impaired glucose tolerance. 

 

Overall, tirzepatide’s dual action on both GLP-1 and GIP pathways contributes to better blood sugar regulation, appetite control, and weight management.

​

Tizepatide is meant to be used alongside lifestyle changes, i.e. changes to food, sleep, and exercise. It is expected that the drug will work best when accompanied by coaching and support from trained professionals. 

​

The recommended starting dosage is 2.5 mg. A patient may be increased in 2.5 mg increments, as tolerated, up to a maximum of 15 mg once weekly. Doses are set and monitored by a Thinifi healthcare provider and may be adjusted to help patients meet their blood sugar, weight loss, and metabolic health goals.